3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB
Identifieur interne : 000B75 ( Main/Exploration ); précédent : 000B74; suivant : 000B763,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB
Auteurs : Guo Chen ; Wei Xie ; Jihoon Nah ; Allan Sauvat ; Peng Liu ; Federico Pietrocola ; Valentina Sica ; Didac Carmona-Gutierrez ; Andreas Zimmermann ; Tobias Pendl ; Jelena Tadic ; Martina Bergmann ; Sebastian J. Hofer ; Lana Domuz ; Sylvie Lachkar ; Maria Markaki ; Nektarios Tavernarakis ; Junichi Sadoshima ; Frank Madeo ; Oliver Kepp ; Guido KroemerSource :
- EMBO Molecular Medicine [ 1757-4676 ] ; 2019.
Abstract
Caloric restriction mimetics (
Url:
DOI: 10.15252/emmm.201910469
PubMed: 31609086
PubMed Central: 6835206
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000509
- to stream Pmc, to step Curation: 000509
- to stream Pmc, to step Checkpoint: 000A97
- to stream Ncbi, to step Merge: 000A99
- to stream Ncbi, to step Curation: 000A99
- to stream Ncbi, to step Checkpoint: 000A99
- to stream Main, to step Merge: 000B75
- to stream Main, to step Curation: 000B75
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors <styled-content style="fixed-case">TFE</styled-content>3 and <styled-content style="fixed-case">TFEB</styled-content></title><author><name sortKey="Chen, Guo" sort="Chen, Guo" uniqKey="Chen G" first="Guo" last="Chen">Guo Chen</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Xie, Wei" sort="Xie, Wei" uniqKey="Xie W" first="Wei" last="Xie">Wei Xie</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Nah, Jihoon" sort="Nah, Jihoon" uniqKey="Nah J" first="Jihoon" last="Nah">Jihoon Nah</name><affiliation><nlm:aff id="emmm201910469-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Sauvat, Allan" sort="Sauvat, Allan" uniqKey="Sauvat A" first="Allan" last="Sauvat">Allan Sauvat</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Liu, Peng" sort="Liu, Peng" uniqKey="Liu P" first="Peng" last="Liu">Peng Liu</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Sica, Valentina" sort="Sica, Valentina" uniqKey="Sica V" first="Valentina" last="Sica">Valentina Sica</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Carmona Utierrez, Didac" sort="Carmona Utierrez, Didac" uniqKey="Carmona Utierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Zimmermann, Andreas" sort="Zimmermann, Andreas" uniqKey="Zimmermann A" first="Andreas" last="Zimmermann">Andreas Zimmermann</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Pendl, Tobias" sort="Pendl, Tobias" uniqKey="Pendl T" first="Tobias" last="Pendl">Tobias Pendl</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Tadic, Jelena" sort="Tadic, Jelena" uniqKey="Tadic J" first="Jelena" last="Tadic">Jelena Tadic</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Bergmann, Martina" sort="Bergmann, Martina" uniqKey="Bergmann M" first="Martina" last="Bergmann">Martina Bergmann</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Hofer, Sebastian J" sort="Hofer, Sebastian J" uniqKey="Hofer S" first="Sebastian J" last="Hofer">Sebastian J. Hofer</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Domuz, Lana" sort="Domuz, Lana" uniqKey="Domuz L" first="Lana" last="Domuz">Lana Domuz</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Lachkar, Sylvie" sort="Lachkar, Sylvie" uniqKey="Lachkar S" first="Sylvie" last="Lachkar">Sylvie Lachkar</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name><affiliation><nlm:aff id="emmm201910469-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name><affiliation><nlm:aff id="emmm201910469-aff-0012"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0013"></nlm:aff></affiliation></author><author><name sortKey="Sadoshima, Junichi" sort="Sadoshima, Junichi" uniqKey="Sadoshima J" first="Junichi" last="Sadoshima">Junichi Sadoshima</name><affiliation><nlm:aff id="emmm201910469-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0014"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0015"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0016"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31609086</idno><idno type="pmc">6835206</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835206</idno><idno type="RBID">PMC:6835206</idno><idno type="doi">10.15252/emmm.201910469</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000509</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000509</idno><idno type="wicri:Area/Pmc/Curation">000509</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000509</idno><idno type="wicri:Area/Pmc/Checkpoint">000A97</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A97</idno><idno type="wicri:Area/Ncbi/Merge">000A99</idno><idno type="wicri:Area/Ncbi/Curation">000A99</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A99</idno><idno type="wicri:doubleKey">1757-4676:2019:Chen G:dimethoxychalcone:induces:autophagy</idno><idno type="wicri:Area/Main/Merge">000B75</idno><idno type="wicri:Area/Main/Curation">000B75</idno><idno type="wicri:Area/Main/Exploration">000B75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors <styled-content style="fixed-case">TFE</styled-content>3 and <styled-content style="fixed-case">TFEB</styled-content></title><author><name sortKey="Chen, Guo" sort="Chen, Guo" uniqKey="Chen G" first="Guo" last="Chen">Guo Chen</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Xie, Wei" sort="Xie, Wei" uniqKey="Xie W" first="Wei" last="Xie">Wei Xie</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Nah, Jihoon" sort="Nah, Jihoon" uniqKey="Nah J" first="Jihoon" last="Nah">Jihoon Nah</name><affiliation><nlm:aff id="emmm201910469-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Sauvat, Allan" sort="Sauvat, Allan" uniqKey="Sauvat A" first="Allan" last="Sauvat">Allan Sauvat</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Liu, Peng" sort="Liu, Peng" uniqKey="Liu P" first="Peng" last="Liu">Peng Liu</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Sica, Valentina" sort="Sica, Valentina" uniqKey="Sica V" first="Valentina" last="Sica">Valentina Sica</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Carmona Utierrez, Didac" sort="Carmona Utierrez, Didac" uniqKey="Carmona Utierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Zimmermann, Andreas" sort="Zimmermann, Andreas" uniqKey="Zimmermann A" first="Andreas" last="Zimmermann">Andreas Zimmermann</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Pendl, Tobias" sort="Pendl, Tobias" uniqKey="Pendl T" first="Tobias" last="Pendl">Tobias Pendl</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Tadic, Jelena" sort="Tadic, Jelena" uniqKey="Tadic J" first="Jelena" last="Tadic">Jelena Tadic</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Bergmann, Martina" sort="Bergmann, Martina" uniqKey="Bergmann M" first="Martina" last="Bergmann">Martina Bergmann</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Hofer, Sebastian J" sort="Hofer, Sebastian J" uniqKey="Hofer S" first="Sebastian J" last="Hofer">Sebastian J. Hofer</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Domuz, Lana" sort="Domuz, Lana" uniqKey="Domuz L" first="Lana" last="Domuz">Lana Domuz</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Lachkar, Sylvie" sort="Lachkar, Sylvie" uniqKey="Lachkar S" first="Sylvie" last="Lachkar">Sylvie Lachkar</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name><affiliation><nlm:aff id="emmm201910469-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name><affiliation><nlm:aff id="emmm201910469-aff-0012"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0013"></nlm:aff></affiliation></author><author><name sortKey="Sadoshima, Junichi" sort="Sadoshima, Junichi" uniqKey="Sadoshima J" first="Junichi" last="Sadoshima">Junichi Sadoshima</name><affiliation><nlm:aff id="emmm201910469-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><affiliation><nlm:aff id="emmm201910469-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation><nlm:aff id="emmm201910469-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0014"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0015"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201910469-aff-0016"></nlm:aff></affiliation></author></analytic><series><title level="j">EMBO Molecular Medicine</title><idno type="ISSN">1757-4676</idno><idno type="eISSN">1757-4684</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Caloric restriction mimetics (<styled-content style="fixed-case">CRM</styled-content>s) are natural or synthetic compounds that mimic the health‐promoting and longevity‐extending effects of caloric restriction. <styled-content style="fixed-case">CRM</styled-content>s provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux in the absence of toxicity. Here, we report the identification of a novel candidate <styled-content style="fixed-case">CRM</styled-content>, namely 3,4‐dimethoxychalcone (3,4‐<styled-content style="fixed-case">DC</styled-content>), among a library of polyphenols. When added to several different human cell lines, 3,4‐<styled-content style="fixed-case">DC</styled-content> induced the deacetylation of cytoplasmic proteins and stimulated autophagic flux. At difference with other well‐characterized <styled-content style="fixed-case">CRM</styled-content>s, 3,4‐<styled-content style="fixed-case">DC</styled-content>, however, required transcription factor <styled-content style="fixed-case">EB</styled-content> (<styled-content style="fixed-case">TFEB</styled-content>)‐ and E3 (<styled-content style="fixed-case">TFE</styled-content>3)‐dependent gene transcription and <styled-content style="fixed-case">mRNA</styled-content> translation to trigger autophagy. 3,4‐<styled-content style="fixed-case">DC</styled-content> stimulated the translocation of <styled-content style="fixed-case">TFEB</styled-content> and <styled-content style="fixed-case">TFE</styled-content>3 into nuclei both <italic>in vitro</italic> and <italic>in vivo</italic>, in hepatocytes and cardiomyocytes. 3,4‐<styled-content style="fixed-case">DC</styled-content> induced autophagy <italic>in vitro</italic> and in mouse organs, mediated autophagy‐dependent cardioprotective effects, and improved the efficacy of anticancer chemotherapy <italic>in vivo</italic>. Altogether, our results suggest that 3,4‐<styled-content style="fixed-case">DC</styled-content> is a novel <styled-content style="fixed-case">CRM</styled-content> with a previously unrecognized mode of action.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bergmann, Martina" sort="Bergmann, Martina" uniqKey="Bergmann M" first="Martina" last="Bergmann">Martina Bergmann</name><name sortKey="Carmona Utierrez, Didac" sort="Carmona Utierrez, Didac" uniqKey="Carmona Utierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><name sortKey="Chen, Guo" sort="Chen, Guo" uniqKey="Chen G" first="Guo" last="Chen">Guo Chen</name><name sortKey="Domuz, Lana" sort="Domuz, Lana" uniqKey="Domuz L" first="Lana" last="Domuz">Lana Domuz</name><name sortKey="Hofer, Sebastian J" sort="Hofer, Sebastian J" uniqKey="Hofer S" first="Sebastian J" last="Hofer">Sebastian J. Hofer</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Lachkar, Sylvie" sort="Lachkar, Sylvie" uniqKey="Lachkar S" first="Sylvie" last="Lachkar">Sylvie Lachkar</name><name sortKey="Liu, Peng" sort="Liu, Peng" uniqKey="Liu P" first="Peng" last="Liu">Peng Liu</name><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name><name sortKey="Nah, Jihoon" sort="Nah, Jihoon" uniqKey="Nah J" first="Jihoon" last="Nah">Jihoon Nah</name><name sortKey="Pendl, Tobias" sort="Pendl, Tobias" uniqKey="Pendl T" first="Tobias" last="Pendl">Tobias Pendl</name><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name><name sortKey="Sadoshima, Junichi" sort="Sadoshima, Junichi" uniqKey="Sadoshima J" first="Junichi" last="Sadoshima">Junichi Sadoshima</name><name sortKey="Sauvat, Allan" sort="Sauvat, Allan" uniqKey="Sauvat A" first="Allan" last="Sauvat">Allan Sauvat</name><name sortKey="Sica, Valentina" sort="Sica, Valentina" uniqKey="Sica V" first="Valentina" last="Sica">Valentina Sica</name><name sortKey="Tadic, Jelena" sort="Tadic, Jelena" uniqKey="Tadic J" first="Jelena" last="Tadic">Jelena Tadic</name><name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name><name sortKey="Xie, Wei" sort="Xie, Wei" uniqKey="Xie W" first="Wei" last="Xie">Wei Xie</name><name sortKey="Zimmermann, Andreas" sort="Zimmermann, Andreas" uniqKey="Zimmermann A" first="Andreas" last="Zimmermann">Andreas Zimmermann</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B75 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B75 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6835206
|texte= 3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31609086" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |